Pharmacokinetics of self-microemulsifyingdrug delivery system albendazole in rat

Objective:The HPLC method was developed for the determination of Albendazole in mouse Plasma.pharmacokinetics of Albendazole Microemulsion in mouse after oral administration were investigated. Methods:The concentration of drug and metabolites in plasma was determined by HPLC,The rats plasma after double doses oral administration of ABZ-SMEDDS and conventional tablet,pharmaceutical product concentration and its metabolites were determined by HPLC.Compared with conventional tablet and pharmaceutical product,the Cmax,Tmax,AUC were determined by DAS pharmacokinetics software. Results:The recovery was over 70%,and the intra-day and inter-day RSD were less than 15%.The pharmacokinetic parameters of powder,conventional tablet and ABZ-SMEDDS were investigated after oral administration to rats at doses of 38mg/L and 76 mg/L.Compared with pure conventional tablet and pharmaceutical product,the relative bioavailability of SMEDDS were increased 2 and 3 times,The curve of plasma concentration versus time was changed. Conclusion:The SMEDDS resulted in a significant promote of ABZ for the oral bioavailability.