Tissue distribution of self-microemulsifying drug delivery system of albendazole in rats

OBJECTIVE To investigate the pharmacokinetics and tissue distribution of albendazole microemulsion in rats after oral administration by HPLC method.METHODS An HPLC method was developed for the assay of albendazole,the conventional tablet and the pharmaceutical crude drug were taken as the control.The rats' plasma drug concentrations and its metabolites after double doses oral administration of ABZ-SMEDDS were determined by HPLC.RESULTS The recovery was over 70%;the intra-day and inter-day RSD were less than 15%.The ABZ-SMEDDS in rats with a wide distribution,and compared with the crude drug and tablets,it had different degrees of increase in all tissues.The descending sequence of ABZ-SMEDDS levels in tissues was as follows: liver,lung,intestine,spleen,kidney,stomach and brain.CONCLUSION As compared with the conventional tablet and pharmaceutical crude drug,ABZ-SMEDDS deliver quickly and extensively to promote absorption of oral drug and improve the distribution of ABZ in tissue.