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2005•Chinese Journal of PharmaceuticalsRequires access

Determination of Water Content in Omeprazole Sodium for Injection by Near Infrared Diffuse Reflectance Spectroscopy

Huang Ying

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Abstract

Near infrared diffuse reflectance spectroscopy was applied to determine the water content in omeprazole sodium for injection. The NIR spectra of 62 samples were collected, and the partial least squares(PLS) method was used to build the model. The calibration model was set up by 50 samples, the root mean square error of cross validation(RMSECV) was 0.136. The validation was set up by 12 samples. The root mean square error of prediction(RMSEP) was 0.074. The correlation coefficient of the control value and prediction value was 0.9966. The average recovery was 99.4% with RSD of 3.2%.

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What this paper is about

Near infrared diffuse reflectance spectroscopy was applied to determine the water content in omeprazole sodium for injection. The NIR spectra of 62 samples were collected, and the partial least squares(PLS) method was used to build the model. The calibration model was set up by 50 samples, the root mean square error of cross validation(RMSECV) was 0.136. The validation was set up by 12 samples. The root mean square error of prediction(RMSEP) was 0.074. The correlation coefficient of the control value and prediction value was 0.9966. The average recovery was 99.4% with RSD of 3.2%.

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Available abstract

Near infrared diffuse reflectance spectroscopy was applied to determine the water content in omeprazole sodium for injection. The NIR spectra of 62 samples were collected, and the partial least squares(PLS) method was used to build the model. The calibration model was set up by 50 samples, the root mean square error of cross validation(RMSECV) was 0.136. The validation was set up by 12 samples. The root mean square error of prediction(RMSEP) was 0.074. The correlation coefficient of the control value and prediction value was 0.9966. The average recovery was 99.4% with RSD of 3.2%.

Key concepts: Chemistry, Partial least squares regression, Diffuse reflectance infrared fourier transform, Near-infrared spectroscopy, Analytical Chemistry (journal), Mean squared error, Correlation coefficient, Calibration

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