Synthesis and Herbicidal Activity of N-[5-(3-Methyl-2,6-dioxo-4-trifluoromethyl-2,3-dihydropyrimidin-1(6H)-yl) phenyl]-N',N'-disubstituted Urea Compounds

In search of safe and low toxin herbicidal compounds, seven N-[5-(3-methyl-2,6-dioxo-4- trifluoromethyl-2,3-dihydropyrimidin-1(6H)-yl)phenyl]-N',N'-disubstituted urea compounds were designed and synthesized. Their structures were confirmed by IR, 1H NMR, LC/MS and elemental analyses. Pre- liminary bioassay showed that most of title compounds had good herbicidal activity, for example, 4c-4f exhibited more than 90% inhibition to Abutilon theophrasti Medic, Amaranthus spinosus, Chenopodium album, Digitaria sanguinalis, Echinochloa crus-galli, and Setaria viridis at active ingredient 75 g a.i./hm2 in post-emergence treatment.