The Expression of Nuclear Factor-kappa B in Pancreatic Tissue of Rats with Severe Acute Pancreatitis

Objective To investigate the potential significance and the expression of nuclear factor-kappa B(NF-κB) in pathogenesis of severe acute pancreatitis(SAP) in rats.Methods Thirty-six SD rats were randomly divided into sham group and SAP group.The serum amylase,the expression of NF-KB in pancreatic tissue and pancreatic pathology were recorded.Results The concentration of serum amylase and the pancreatic histologic score in SAP group were significantly higher than those in sham group(P0.01).The expression of NF-κB in SAP group was persistencely upgraded after 3 hour,while there was no marked expression in sham group(P(0.01)).Conclusion NF-κB is involved in the inflammation response of SAP.The expression of NF-κB has a positive correlation with pathology damage of pancreatic tissue.Inhibition of the expression of NF-κB in pancreatic tissue may be helpful for treatment of SAP.