Fluvoxamine combined with Sulpiride in the treatment of depression with psycholic symptoms

Objective To explore the curative effect and safety of fluvoxamine combining sulpiride in the treatment of depression with psychotic symptoms.Method A total of 103 depressive patients with psychotic symptoms were randomly divided into fluvoxamine combined with sulpiride group(study group,n=52) or single fluvoxamine group(control group,n=46) for 8 weeks.The Clinical efficacy,Hamilton Depression Rating Scale(HAMD),Brief Psychiatric Rating Scale(BPRS) and Treatment Emergent Symptoms Scale(TESS) were used to evaluate efficacy and adverse effects.Results Compared with pretreatment,scores of the BPRS and HAMD in each week after treatment significantly decreased in two groups(P0.01).The rates of recovery and markedly effection in study group were significantly higher than that of control group.The total scores,factor scores of thought disorder,hostility and suspicious,activity of BPRS,and total scores,factor scores of inhibition and body weight of HAMD in study group were significantly lower than that of control grop.Conclusion Fluoxetine combining with low dose sulpiride would have better efficacy and fewer adverse effects than flunetive.