2010•Zhonghua zhongyiyao xuekanRequires access
Effect of Rouganxiaozheng Liquid on the Content of Nitrogen Monoxidum and Endothelin in Serum of Hepatic Cirrhotic Rats
Han Xue
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Abstract
Objective:To observe the effect of Rouganxiaozheng liquid on the content of nitrogen monoxidum(NO)and endothelin1(ET-1) in serum of hepatic cirrhotic rats.Methods:The model of hepatic cirrhosis were made by composite factor,which were devided into five groups,that is normal group,model group,control group(Fufangbiejiaruangan tablet),high and low Rouganxiaozheng group,the effect of Rouganxiaozheng on hepatic tissue Pathological histology and the content of NO and ET-1 in serum were observed.Results:Compared with normal group,the normal hepatic lobules in model group were disappeared and fibroplasias formed nodus and false folial;The content of NO and ET-1 in serum were increased obviously.Compared with model group,the pathological histology of each treatment group were improved,the content of NO and ET-1 were decreased apparently.Conclusion:Rouganxiaozheng liquid could obviously decrease the content of NO and ET-1 of cirrhosis rats,and resist hepatic cirrhosis.