2007•Chinese journal of integrated traditional and Western medicineRequires access
Effect of Rougan Xiaozheng (RGXZ) liquid on the content of IL-1β、IL-6 of in serum and liver tissue of heaptic cirrhotic rats
Yixin Zhang
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Abstract
Objective:To observe the effect of RGXZ liquid on hepatic pathological histology and the content of IL-1β and IL-6 in serum and liver tissue of hepatic cirrhosis rats.Methods:To make the model of hepatic cirrhosis by composite factors,compared with Fufangbiejiaruangan tablet,the effect of RGXZ liquid on hepatic tissue pathological histology and the content of IL-1β and IL-6 in serum and liver tissue were observed.Results:Compared with normal group,the normal hepatic lobules in model group were disappeared and fibroplasias formed nodus and false folial.The content of IL-1β and IL-6 in serum and the content of IL-6 in liver tissue were increased obviously(P0.01 or P0.05).Compared with model group,the pathological histology of each treatment group were improved,the content of IL-1β in serum and the content of IL-6 in liver tissue of each treatment group were decreased evidently(P0.01 or P0.05).Compared with control group,the content of IL-6 in serum of high-dose group were decreased apparently(P0.05).Conclusion:RGXZ liquid could obviously decrease the content of IL-1β、IL-6 serum and the content of IL-6 in liver tissue of cirrhosis rats,and lighten inflammation damage,as well as improve pathological histology.