Expression of ID-2 Protein in Esophageal Squamous Cell Carcinoma (ESCC) and Its Relationship with Tumor Angiogenesis

[Purpose] To investigate the expression of ID-2 protein in esophageal squamous cell carcinoma (ESCC) and its relationship with tumor angiogenesis.[Methods] The expression of ID-2 in 115 cases of surgical resected ESCC tissue specimens and 60 negative margin tissues as control were examined by SP immunohistochemical staining. The relationships of the expression of ID-2 with carcinogensis of esophageal squamous cell carcinoma and MVD were analyzed. [Results] The positive expression rate of ID-2 was 85.2%(98/115) in ESCC tissues and 15.0% (9/60) in negative margin tissues,with significantly different (P0.01). The expression of ID-2 related to depth of tumor invasion,MVD,tumor stage and differentiation(P0.05),but didn't relate to the age,gender,depth of invasion and lymphatic metastasis (P0.05). High expression of ID-2 had a worse prognosis (P0.05). [Conclusion] Expression of ID-2 plays an important role in tumorigenesis,tumor angiogenesis in ESCC. ID-2 may be one of important agents in promoting tumor angiogenesis in ESCC. High expression of ID-2 may shorten survival.