The clinical observation of applying dinoprostone suppositories to ripen the cervix and induce labor in term pregnancies

Objective:To evaluate the efficacy and safety of continuously released dinoprostone suppositories-prostaglandin E_2 pessary for cervical repening and inducation labor in term pregnancies.Methods:135 cases term pregnant women were randomly divided into two groups,90 cases as study group received a dinoprostone suppositories pessary(10mg)inserting into vaginal,while 45 cases as control group received transvenous injecting sodium prasterone sulfate of 200 mg/d.After 3 days both groups received transvenous dripping 2.5 U oxytocin.The cervical mature(by Bishop scroring),labor condition and the achievement ratio of induction delivery were compared between two groups.Results:The efficacy of ripening cervix in study group was obviously superior to that in control group(P0.01).Time to labor starting and membrane rupture in study group were both shorter than that in control group(P0.01).Achievement ratio of induction delivery in study group was higher than that in control group(P0.05).Cesarean section rate in study group was lower than that in control group(P0.05).No significant differences were found in time from labor starting to delivery,postpartum hemorrhage,fetal distress and apnoea neonatorum between the two groups(P0.05).Conclusion:Dinoprostone suppositories is effective in producing cervical ripening and induction labor,and can be used safely in clinic.