Clinical observation of dinoprostone suppositories and oxytocin for labor induction in full-term pregnancy

Objective:To explore the efficacy and safety of dinoprostone suppositories for cervical ripening and labor induction in full-term pregnancy.Methods:220 cases of full-term pregnant wonen who were with single fetus,head presentation and without any vaginal delivery contraindication were divided into two groups according to the randomized double-blind study.The observation group(n=110) were placed a piece of dinoprostone suppositories in posterior fornix,the control group were treated with oxytocin in the induction process.The changes of cervical ripening(Bishop),the success rate of labor induction,the total stages of labor,the vaginal elivery rate,the influence on fetus and newborns were observed as the clinical evaluation after the treatment.Results:The degree of cervical ripening in the observation group was higher than in the control group(P0.01);the interval from medication to labor was shorter(P0.01).The 12 h labor rate was 67.3% and the 24 h labor rate was 87.3% in the observation group;the 12 h labor rate was 46.4% and the 24 h labor rate was 70.0% in the control group;the differences of the two groups were significant(P0.01).The success rate of labor induction in the observation group was higher than that in the control group.The vaginal elivery rate was 65.5% in the observation group and 51.8% in the control group(P0.05).The influence on mother and infant in the two groups showed no significant difference.Conclusion:Dinoprostone suppositories can increase the degree of cervical ripening and contract uterine revulsant,which is superior to those of oxytocin.Dnoprostone suppositories can significantly increase Bishop score and the vaginal elivery rate,which is convenience,safety,efficiency,and is worthy of clinical application in obstetrics.