Clinical effect of compound anti-fulminant hepatitis and its influence on cytokines and T cell subsets for the treatment of severe hepatitis B

Objective:To investigate the effect of compound anti-fulminant hepatitis on cytokines and T cell subsets in patients with severe hepatitis B.Methods:Sixty patients were randomly divided into 2 groups,that was,30 patients treated with conventional western medicine plus compound anti-fulminant hepatitis in the treated group,which was taken 100ml each time,3 times a day and 14 days as a treating course,30patients treated with conventional western medicine alone as a control group.The patients were treated 2～4 treating course.TBil,ALT,Alb,PTA,T-Chol were tested.The levels of T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+),interler leukine(IL-6,IL-8),and tumor necrosis factor-α(TNF-α)were determined by using flow cytometer and ELISA before treatment and at the end 2 treating course of treatment respectively.Results:Marked improvement rate was 43.3% and total effective rate was 70.0% in treatment group,compared to 20.0% and 53.3% in control group.The difference was significant(P0.05).By the end of the 2 treating course,the levels of IL-6,IL-8,TNF-α,CD3+,CD4+,CD8+,CD4+/CD8+ in the treated group were significantly higher than control group(P0.05).Conclusion:Compound anti-fulminant hepatitis is helpful to improve prognosis of acute,subacute and chronic severe hepatitis and one of the effective measures to improve overal treatment of severe hepatitis.Compound anti-fulminant hepatitis can positively regulate the immune function of patients with severe hepatitis patients in certain.