ScholarLens Back to search
2005•Chinese Journal of Geriatric Cardiovascular and Cerebrovascular DiseaseRequires access

469K/E polymorphism of the ICAM-1 gene and the elderly with coronary heart disease

Pei-e Wen

Open publisher page 0 citations

Abstract

Objective To observe the relationship between intercellular adhesion molecule -1 (ICAM-1) gene 469K/E polymorphism and CHD in the elderly.Methods 122 controls and 117 patients with CHD were cnrolled.All patients and controls were genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques (nested PCR) for the ICAM-1 polymorphism.Results Genotype distribution was in accordance with Hardy-Weinberg equilibrium. The frequency of (KK+KE) genotype was much higher than that of EE in CHD, which had significant difference with the control (P=0.011). By means of binary logistic regression analysis, it was found that K genotype and smoking enhanced the risk of CHD, and that there was a synergistic action between K genotype and smoking which can influence the risk of CHD.Conclusions ICAM-1 gene 469K/E polymorphism has a relationship with CHD in the elderly, and K genotype may be one of the genetic factors influencing the risk of CHD.

About this research paper

What this paper is about

Objective To observe the relationship between intercellular adhesion molecule -1 (ICAM-1) gene 469K/E polymorphism and CHD in the elderly.Methods 122 controls and 117 patients with CHD were cnrolled.All patients and controls were genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques (nested PCR) for the ICAM-1 polymorphism.Results Genotype distribution was in accordance with Hardy-Weinberg equilibrium. The frequency of (KK+KE) genotype was much higher than that of EE in CHD, which had significant difference with the control (P=0.011). By means of binary logistic regression analysis, it was found that K genotype and smoking enhanced the risk of CHD, and that there was a synergistic action between K genotype and smoking which can influence the risk of CHD.Conclusions ICAM-1 gene 469K/E polymorphism has a relationship with CHD in the elderly, and K genotype may be one of the genetic factors influencing the risk of CHD.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To observe the relationship between intercellular adhesion molecule -1 (ICAM-1) gene 469K/E polymorphism and CHD in the elderly.Methods 122 controls and 117 patients with CHD were cnrolled.All patients and controls were genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques (nested PCR) for the ICAM-1 polymorphism.Results Genotype distribution was in accordance with Hardy-Weinberg equilibrium. The frequency of (KK+KE) genotype was much higher than that of EE in CHD, which had significant difference with the control (P=0.011). By means of binary logistic regression analysis, it was found that K genotype and smoking enhanced the risk of CHD, and that there was a synergistic action between K genotype and smoking which can influence the risk of CHD.Conclusions ICAM-1 gene 469K/E polymorphism has a relationship with CHD in the elderly, and K genotype may be one of the genetic factors influencing the risk of CHD.

Key concepts: Genotype, Medicine, Allele, Coronary heart disease, Internal medicine, Logistic regression, Polymorphism (computer science), Gene polymorphism

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
469K/E polymorphism of the ICAM-1 gene and the elderly with coronary heart disease — Research Paper | ScholarLens