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Study on Extraction Technology of Berberine from Rhizoma Coptidis by the Method of Orthogonal-test Optimization

Zhang Shan-tang

Abstract

OBJECTIVE:To optimize the extraction technology of berberine from Rhizoma Coptidis.METHODS:The orˉthogonal-test method was adopted to research the effects of5factors,including the concentration and volume of alcohol,the concentration of H 2 SO 4 ,the duration and times of extraction on the yielding rate of berberine from Rhizoma Coptidis.RESUL TS:The optimum technology of extracting berberine from Rhizoma Coptidis was described as follows:The concentration of alˉcohol containing0.25%H 2 SO 4 was80%,and volume of alcohol was6times raw herb.To extract the herb for3times was optimum and duration of extraction was1.5h for each time.CONCLUSION:The content of berberine in the product is over90%,so this technology is suitable for industrialized production.

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Key concepts: Berberine, Herb, Extraction (chemistry), Traditional medicine, Chromatography, Chemistry, Medicinal herbs, Medicine