Clinical comparative study of Propafenone and Amiodarone treatment on paroxysmal supraventricular tachycardia

Objective To explore the effect and safety of intravenous Propafenone and Amiodarone treatment on paroxysmal supraventricular tachycardia(PSVT).Methods Eighty-six patients of PSVT who were admitted our hospital from January 2009 to January 2012 were randomly divided into two groups,intravenous Propafenone group(n = 45) and intravenous Amiodarone group(n = 41).Comparition of the termination rate and adverse events rate were observed between the two groups.Results The time of heart beat recovery in Propafenone group were(8.14±1.80) min and Amiodarone group were(19.31±2.95) min,there had difference of statistical significance between the two groups(t = 21.58,P 0.05).The termination rate of PSVT was 84.44%(38/45)in Propafenone group and 85.37%(35/41) in Amiodarone group,showed no significant difference(χ2=0.12,P 0.05).The incidence rates of side effect were respectively without significant difference(22.22% vs 21.95%,χ2=0.01,P 0.05).Conclusion Intravenous Propafenone and Amiodarone treatment on clonic paroxysmal supraventricular tachycardia is safe,effective and can be used as a drug treatment PSVT line.