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Effects of Berberine,Chlorogenic Acid and Baicalin on the Expression of ICAM-1 in Rat Intestinal Mucosa Microvascular Endothelial Cells Injured by LPS

Xiang Mu

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Abstract

To investigate their anti-inflammatory mechanism,the effects of berberine(Ber.),chlorogenic acid(Ch.A.) and baicalin(Bai) on the expression of intercellular adhesion molecule 1(ICAM-1) in rat intestinal mucosa microvascular endothelial cells(RIMMVECs) challeged by lipopolysaccharide(LPS) were analyzed by immunocytochemical staining,and gray scale and statistical analysis were performed.The results showed that RIMMVECs constitutively express ICAM-1 in low level and LPS significantly increased it,while LPS-induced strong expression of ICAM-1 in RIMMVECs was suppressed by Ber,Ch.A and Bai.The results indicated that the anti-inflammatory role of Ber,Ch.A and Bai is related to their downregulating effect on LPS-mediated ICAM-1 expression, which provide data for clarifying their mechanism.

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What this paper is about

To investigate their anti-inflammatory mechanism,the effects of berberine(Ber.),chlorogenic acid(Ch.A.) and baicalin(Bai) on the expression of intercellular adhesion molecule 1(ICAM-1) in rat intestinal mucosa microvascular endothelial cells(RIMMVECs) challeged by lipopolysaccharide(LPS) were analyzed by immunocytochemical staining,and gray scale and statistical analysis were performed.The results showed that RIMMVECs constitutively express ICAM-1 in low level and LPS significantly increased it,while LPS-induced strong expression of ICAM-1 in RIMMVECs was suppressed by Ber,Ch.A and Bai.The results indicated that the anti-inflammatory role of Ber,Ch.A and Bai is related to their downregulating effect on LPS-mediated ICAM-1 expression, which provide data for clarifying their mechanism.

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Available abstract

To investigate their anti-inflammatory mechanism,the effects of berberine(Ber.),chlorogenic acid(Ch.A.) and baicalin(Bai) on the expression of intercellular adhesion molecule 1(ICAM-1) in rat intestinal mucosa microvascular endothelial cells(RIMMVECs) challeged by lipopolysaccharide(LPS) were analyzed by immunocytochemical staining,and gray scale and statistical analysis were performed.The results showed that RIMMVECs constitutively express ICAM-1 in low level and LPS significantly increased it,while LPS-induced strong expression of ICAM-1 in RIMMVECs was suppressed by Ber,Ch.A and Bai.The results indicated that the anti-inflammatory role of Ber,Ch.A and Bai is related to their downregulating effect on LPS-mediated ICAM-1 expression, which provide data for clarifying their mechanism.

Key concepts: Berberine, Lipopolysaccharide, Biology, Chlorogenic acid, ICAM-1, Intercellular Adhesion Molecule-1, Molecular biology, Decoction

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Effects of Berberine,Chlorogenic Acid and Baicalin on the Expression of ICAM-1 in Rat Intestinal Mucosa Microvascular Endothelial Cells Injured by LPS — Research Paper | ScholarLens