Effects of Calcium Antagonist on the Plasma Vascular Active peptides \;Level in Patients with Essential Hypertension

Aim:To investigate the effects of calcium antagonist on the levels of plasma neuropeptide Y(NPY), neurotensin(NT), endothelin(ET) and calcitonin gene related peptide(CGRP) and their effects in the pathogenesis of essential hypertension. Methods:The levels of plasma NPY,ET,NT and CGRP by radio immunoassay method were measured in 62 patients with essential hypertension and 50 healthy controls. Results:The levels of plasma ET, NPY of the patients with essential hypertension were significantly higher than those in healthy controls, the levels of plasma CGRP, [WT5”,6BZ]NT were significantly lower than those in healthy controls. There are positive correlation of DBP and ET、NPY . After treatment, the levels of SBP and DBP、ET and NPY were decreased obviously, the levels of CGRP、NT were increased significantly. Conclusions:The levels of plasma NPY、NT、ET and CGRP may play an important roles in the pathogenesis of essential hypertension, Calcium antagonist have an vital role in protecting target organs by means of the regulation of plasma levels of vascular active peptides,the effect of felodipine was stronger than that of diltiazem.