Effect of prostaglandin-E_1 on plasma endothelin and calcitonin gene related peptide in chronic renal failure

AIM To observe the effect of prostaglandin E1 (PGE 1) on plasma endothelin (ET) and calcitonin gene related peptide (CGRP) in chronic renal failure (CRF). METHODS The RIA method was used to detect the concentration of plasma ET and CGRP by PGE 1 treatment in 90 cases with CRF and 78 normal cases as control. RESULTS The results showed that plasma ET levels in patients with CRF were significantly higher than those in controls( P 0.01). The levels of plasma CGRP in patients with CRF were significantly lower than those in controls( P 0.01). The concentration of plasma ET was correlated with the parameter of renal function (BUN, Cr)( r =0.58, P 0.01 and r =0.62, P 0.01) and there was a negative correlation between the plasma ET levels and the volume of urine( r =-0.60, P 0.01). After the treatment with PGE 1, the parameters mentioned above improved ( P 0.05)and so did the parameters of renal function (BUN, CR, Urine)( P 0.05). CONCLUSION It is concluded that the concentration of plasma ET and CGRP is always changed in CRF patients. The application of prostaglandin E 1 in the treatment of chronic renal failure is beneficial to delay the deterioration of renal function.