Expression and clinical significance of matrix met alloproteinase-9 and E-cadherin in pancreatic cancer

Objective To observe the expression and of matrix met alloproteinase 9 protein(MMP-9) and E-cadherin protein(E-cad) in pancreatic cancer,and to investigate the correlation and clinical significance of MMP-9 and E-cad proteins expression.Methods Expression of MMP-9 and E-cad in 15 normal tissue specimens,30 specimens of Insulinoma and 50 specimens of pancreatic cancer was determined by immunohistochemical staining,and relationship between MMP-9 and E-cad expression and pathological features in pancreatic cancer.Results The positive rate of MMP-9 and E-cad 82%,24%.The expression of MMP-9 and in the tissue of pancreatic cancer was significantly higher than that in Insulinoma and normal pancreas.The expression of E-cad in the tissue of pancreatic cancer was significantly lower than that in Insulinoma and normal pancreas(P0.05).The expression of MMP-9 and E-cad protein was associated with lymphatic metastasis and pathological types(P0.05).The expression of MMP-9 and E-cad protein were negative correlated in pancreatic cancer(P0.05).Conclusion MMP-9 and E-cad proteins play a critical role in tumor metastasis.Co-detection of the expression of MMP-9 and E-cad can be used to predict the metastatic potential of Pancreatic Cancer,and can effectively evaluate the prognosis of patients with pancreatic cancer.