The expression of S100A4 and MMP2 in pancreatic cancer and its relationship with infiltration,metastasis and prognosis of pancreatic cancer

Objective To observe the expressions of metastasis-associated protein (S100A4) and matrix metalloproteinase 2(MMP2) in pancreatic cancer,insulinoma and normal pancreas,and investigate their correlations with the infiltration, metastasis and prognosis of pancreatic cancer. Methods The expression of S100A4 and MMP2 proteins was detected by immunohistochemistry with SP method in 82 specimens of pancreatic cancer,43 specimens of insulinoma and 21 normal tissue specimens. Results The positive rates of S100A4 and MMP-2 were 69.51% and 58.54% in pancreatic cancer tissue. The expression of S100A4 and MMP2 in the tissue of pancreatic cancer was significantly higher than that in insulinoma and normal pancreas(P<0.05). The expression of S100A4 and MMP2 protein was associated with tumor size,lymphatic metastasis,TNM stages,pathological types and CA199 quantitative value (P<0.05). The expression of S100A4 and MMP2 protein were positive correlated with pancreatic cancer (P<0.05) .Univariate survival analysis confirmed expressions of Sl00A4 and MMP2 on survival time of pancreatic cancer patients(P<0.05). Conclusions S100A4 and MMP-2 proteins play a critical role in tumor metastasis. Co-detection of the expression of S100A4 and MMP-2 can be used to predict the metastatic potential of pancreatic cancer, and can effectively evaluate the prognosis of patients with pancreatic cancer. Key words: Pancreatic cancer; S100A4; MMP2; Immunohistochemistry; Prognosis