Role of high-risk HPV16,18 DNA in early cervical dysplasia and cervical carcinoma

Objective:To explore the relationship beteen HPV16,18 and early dysplasia as well as cervical carcinoma by examining the infection with human HPV16,18 in early cervical dysplasia and cervical carcinoma.Methods: All specimens were detected for HPV16,18 DNA using techniques of fluorescence quantitative polymerase chain reaction(FQ-PCR).The pathological changes were graded based on CIN criteria.CINⅡ-Ⅲ were the early cervical dysplasia of cervical cancer.Results: The cervical tissue HPV16,18 infection rate of CINⅡ-Ⅲ patients was 67.6%.The detection rate of HPV16,18 in cervicl cancer patients was 91.8%.The detection rate of HPV16,18 in chronic cervicitis patients was 28.6%.Conclusion: The development of cervical carcinoma and early cervical dysplasia were associated with an increased risk of HPV16,18 infection.The detection of high-risk HPV16,18 DNA provides application value for the forcast and theraphy of cervical carcinoma.