Relationship between the levels of nitric oxide and glucose in cord blood and prognosis in newborn with asphyxia

Objective To investigate the changes of nitric oxide (NO)and glucose in cord blood in newborns with asphyxia . Methods The levels of NO and glucose in cord blood were determined in 30 newborns with asphyxia,and 32 healthy neonates. Results The levels of NO - 2 and glucose in cord blood were 27.28±9.52μmol·L -1 and 3.65±0.79mmol·L -1 respectively in the control group,and 43.74±13.20μmol·L -1 and 5.65±1.20mmol·L -1 in the asphyxia group.The levels of NO - 2 and glucose levels in cord blood in the newborns with asphyxia were much higher than those in the normal controls.The levels of NO - 2 and glucose levels in cord blood in the newborns with severe asphyxia(60.17±9.93μmol·L -1 and 7.25±0.54mmol·L -1 )were found to be significantly higher than those seen in the light asphyxia group(36.72±6.33μmol·L -1 and 4.93±0.53mmol·L -1 ,P0.01).The NO levels were significantly related to the glucose levels.Moreover,the cord blood No level was related closely to development of hypoxia-ischemic encephalopathy. Conclusion The determinations of NO and glucose in cord blood in newborns with asphyxia have important clinical significance.