2008•Pharmaceutical and Clinical ResearchRequires access
Determination of the active compounds of Panax notoginseng and Panax ginseng in Kangerxin capsules
Haiyan Luo
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Abstract
Objective:To develop a method for the determination of active compounds of Panax notoginseng and Panax ginseng in Kangerxin capsules.Methods: The diamonsil C18 column(250 mm×4.6 mm,5 μm)was used with acetonitrile as the mobile phase A and water as the mobile phase B.The linear grade is 0～9.5min,A27%;9.5～15 min,A 27%～45%;15～22 min,A45%;22～23min,A45%～27%;23～30 min,A 27%.The flow rate was 1.0 mL·min-1.The temperature of column is 35℃.Results: The linear ranges of ginsenoside Rg1,Rb1,notoginsenoside R1 in Kangerxin capsules were 0.0396～0.1584μg,0.04076～0.16304μg,0.0412～0.1648 μg respectively.The average recoveris were 100.20%、 100.13%、 99.68% respectively.RSD were 0.38%,0.39%、0.36%respectively.Conclusion: This method is convenient,reliable and stable for the determination of the quality control of Kangerxin capsules.