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2012•Journal of Zhengzhou UniversityRequires access

Expressions of CD147,MMP-9 and AnnexinII in breast invasive ductal carcinoma tissue

Dang Qiuhong

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Abstract

Aim:To detect the expressions of CD147,MMP-9 and AnnexinⅡ in breast invasive ductal carcinoma tissue.Methods:The expressions of CD147,MMP-9 and AnnexinⅡ in 60 cases of breast invasive ductal carcinoma and 60 cases of breast fibroadenoma were detected by immunohistochemistry.Results:The positive expression rates of CD147,MMP-9 and AnnexinⅡ in the breast invasive ductal carcinoma were 91.7%,86.7% and 90.0%,respectively,which were significantly higher than those in breast fibroadenoma(6.7%,6.7% and 3.3%,P0.001).In lymph node metastatic group,the positive expression rates of CD147,MMP-9 and AnnexinⅡ in the breast invasive ductal carcinoma were higher than those in no lymph node metastatic group(P0.05).The positive expression rates of CD147,MMP-9 and AnnexinⅡ increased with the increase of histological grade(P0.05).Conclusion:The abnormal high expressions of CD147,MMP-9 and AnnexinⅡ may prompt the development of beast invasive ductal carcinoma.

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Aim:To detect the expressions of CD147,MMP-9 and AnnexinⅡ in breast invasive ductal carcinoma tissue.Methods:The expressions of CD147,MMP-9 and AnnexinⅡ in 60 cases of breast invasive ductal carcinoma and 60 cases of breast fibroadenoma were detected by immunohistochemistry.Results:The positive expression rates of CD147,MMP-9 and AnnexinⅡ in the breast invasive ductal carcinoma were 91.7%,86.7% and 90.0%,respectively,which were significantly higher than those in breast fibroadenoma(6.7%,6.7% and 3.3%,P0.001).In lymph node metastatic group,the positive expression rates of CD147,MMP-9 and AnnexinⅡ in the breast invasive ductal carcinoma were higher than those in no lymph node metastatic group(P0.05).The positive expression rates of CD147,MMP-9 and AnnexinⅡ increased with the increase of histological grade(P0.05).Conclusion:The abnormal high expressions of CD147,MMP-9 and AnnexinⅡ may prompt the development of beast invasive ductal carcinoma.

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Available abstract

Aim:To detect the expressions of CD147,MMP-9 and AnnexinⅡ in breast invasive ductal carcinoma tissue.Methods:The expressions of CD147,MMP-9 and AnnexinⅡ in 60 cases of breast invasive ductal carcinoma and 60 cases of breast fibroadenoma were detected by immunohistochemistry.Results:The positive expression rates of CD147,MMP-9 and AnnexinⅡ in the breast invasive ductal carcinoma were 91.7%,86.7% and 90.0%,respectively,which were significantly higher than those in breast fibroadenoma(6.7%,6.7% and 3.3%,P0.001).In lymph node metastatic group,the positive expression rates of CD147,MMP-9 and AnnexinⅡ in the breast invasive ductal carcinoma were higher than those in no lymph node metastatic group(P0.05).The positive expression rates of CD147,MMP-9 and AnnexinⅡ increased with the increase of histological grade(P0.05).Conclusion:The abnormal high expressions of CD147,MMP-9 and AnnexinⅡ may prompt the development of beast invasive ductal carcinoma.

Key concepts: Fibroadenoma, Invasive ductal carcinoma, Medicine, Immunohistochemistry, Ductal carcinoma, Breast Fibroadenoma, Lymph node, Pathology

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