Expression and clinical significance of MMP-3 in breast ductal carcinomas

Objective:To detect the expression of MMP-3 in breast ductal carcinomas,and explore its significance and the relationship with clinical parameters.Methods:The expression of MMP-3 was detected in 48 cases of breast ductal carcinomas by immunohistochemistry MaxVision,and to analyze the relation between MMP-3 and breast ductal carcinomas patient age,tumor size,histological type,lymph node metastasis,ER,PR,E-cad and C-erbB-2.Results:MMP-3 in breast ductal carcinomas positive rate was significantly higher than normal breast tissue(P0.05).MMP-3 rate in patients without lymph node metastasis and positive C-erbB-2 was significantly higher than those in the control group(P0.05);but in different age,tumor size,histological type and ER,PR,E-cad and C-erbB-2 no significant difference(P0.05).Conclusion:MMP-3 is highly expressed in patients without lymph node metastasis and early stages of breast ductal carcinomas MMP-3 in C-erbB-2 positive breast ductal carcinomas is significantly higher expressed,combined detecton of these two indexes in predicting the prognosis of ductal breast cancer could have important implications.