Clinical study of thinprep cytologic test(TCT) combined with biopsy under colposcpy in diagnosis of cervical squamous intraepithelial lesions

Objective To investigate the effectiveness of thinprep cytologic test(TCT)combined with biopsy under colposcopy for diagnosis of cervical squamous intraepithelial lesions(CIN).Methods 519 suspicious patients were assigned to receive TCT combined with biopsy under colposcopy(TCT group,268 patients) or biopsy under colposcopy randomly(control group,251 patients).Pathologic examination of biopsy sample was used as gold standard.Results The coincidence on diagnosis of cervical lesions between TCT group and pathologic examination of biopsy sample was 72.0%(193/268),the coincidence on diagnosis of cervical lesions between control group and pathologic examination of biopsy sample was 50.1%(126/251),the difference was significant(χ2=388.62,P0.005).Conclusion TCT combined with biopsy under colposcopy may be a reliable method to screen and diagnose the precancerosis of cervix.