Studies on Protective Immune Mechanism of Recombinant 31/32kDa Schistosoma Japonicum Antigen

Objective To study the effect of antibody in the protective immune mechanism of recombinant 31/32kDa schistosoma japonicum antigen(rSj31/32).Methods Rabbits were vaccinated multiply with rSj31/32,of which the level of IgG antibody in serum was observed dynamically.At the same time,sera with rSj31/32 vaccinated rabbits(rSj31/32-VRS) and IRS transfered passively to mice at different time to detect the protecting resistant.Results The passive transfer of rSj31/32-VRS before challenge could induce 32.6% worm reduction rate and 65.0% egg reduction rate,higher than that after challenge(18.5%).The rSj31/32-VRS level of IgG rose at week 3,reached the peak at week 4 and then gradually dropped off.Conclusion Antibody might play an important role in the protective immunity elicited by rSj31/32.