Detection of Four Items Blood Coagulation and D-dimer in Women in Mid-late Pregnancy and its Clinical Significance

Objective To detect the result of four items blood coagulation and plasma D-dimer in healthy women in mid-late women,so as to understand their coagulation and fibrinolysis.Methods Four items blood coagulation were assayed with coagulation method,and D-dimer with immune-turbidity method.Both were tested on sysmex Ca-7000 full-Automatic coagulation analyzer.Results Compared with the healthy non-pregnant women,women in mid-late pregnancy had shorter PT and APTT(P0.05),and higher FIB(P0.01).There was no evident difference on TT(P0.05).The significant difference was also found in D-dimer level between the two groups(P0.05).Conclusions Due to enhanced coagulation and decreased fibrinolytic activity,hypercoagulability usually occurs in mid-late pregnancy,which is useful to stop post-partum bleeding rapidly and effectively.Therefore,it is clinically important to examine the coagulation function prenatally,especially to avoid obstetric complications such as DIC and amniotic fluid embolism.