Analysis of variation of women's blood coagulation function in normal pregnancy

Objective To investigate the variation of coagulation function in pregnancy.Methods Prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(Fbg),D-Dimer(D-D) and antithrombin Ⅲ(AT-Ⅲ)in fifty-two pregnant women and twenty normal non-pregnency women were determined by ACL-9000 system.Results Compared with those of the control group,the levels of PT,APTT were not obviously changed in pregnancy(P0.05);the levels of TT were obviously shorter compared with the late-pregnant women and the other group(P0.01);but there was no significant difference among the control group,the early and middle pregnant women groups(P0.05);compared with the control group,the activity of AT-Ⅲ were obviously dropped in pregnancy(P0.01),and decreased with the progress of pregnancy(P0.01);in contrast,the levels of D-D and Fg increased with the progress pregnancy(P0.01).Conclusion The pregnant women have the hypercoagulation state.The detection of blood concretion functions plays an important role in preventing from complications.