2011•Zhongguo laonianxue zazhiRequires access
Effect of eye acupuncture therapy on brain-derived neurotrophic factor expr ession in acute cerebral ischemia-reperfusion injury rats
Wang De
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Abstract
Objective To investigate the effect of eye acupuncture therapy on cerebral brain-derived neurotrophic factor(BDNF) expres sion in rats with cerebral ischemia-reperfusion injury and the related mechanis m. Methods Rat model of cerebral ischemia-reperfusion was e stablished by suture method.The methods of immunohistochemistry staining,West ern-blotting and RQ-PCR were taken to detect the alteration of the BDNF protei n and BDNF mRNA in rat brains after eye acupuncture therapy. Results Compared with the model group,the neurologic imp airment sco re of the eye-acupuncture group was decreased obviously and the expression of t h e BDNF protein and BDNF mRNA in rat brains after eye acupuncture therapy was str ongly increased(P0.05). Conclusions Eye acupuncture therapy can reduce the ce rebral ischemia-reperfusion injury evidently by increasing the expression of th e cerebral BDNF protein.