ScholarLens Back to search
2002•Unpublished venueRequires access

THE EXPRESSION OF bcl-2,bax PROTEIN AND p53mRNA IN LUNG CANCER

Shi Mei

Open publisher page 0 citations

Abstract

Objective:To investigate the relationship between expression of p53mRNA and bcl 2,bax protein,and their clinicopathologic features.Methods:Expression of bcl 2,bax protein and p53mRNA in 52 cases of surgically resected primary lung cancer were investigated respectively by immunohistochemical and RT PCR techniques.Results:The positive expression of bcl 2,bax protein was observed in 52(42.3 % vs 59.61 %) cases.The bcl 2 expression rate was much higher in those with poor differentiation and in stage Ⅲ than those with well differentiation and stage Ⅰ ( P 0.01).Conclusion:Overexpression of bcl 2 protein is predominantly observed in lung cancer at late stage;p53mRNA and bax protein play a key role in early stage.They modulate and co operate the balance status of death and survival signals in cells.

About this research paper

What this paper is about

Objective:To investigate the relationship between expression of p53mRNA and bcl 2,bax protein,and their clinicopathologic features.Methods:Expression of bcl 2,bax protein and p53mRNA in 52 cases of surgically resected primary lung cancer were investigated respectively by immunohistochemical and RT PCR techniques.Results:The positive expression of bcl 2,bax protein was observed in 52(42.3 % vs 59.61 %) cases.The bcl 2 expression rate was much higher in those with poor differentiation and in stage Ⅲ than those with well differentiation and stage Ⅰ ( P 0.01).Conclusion:Overexpression of bcl 2 protein is predominantly observed in lung cancer at late stage;p53mRNA and bax protein play a key role in early stage.They modulate and co operate the balance status of death and survival signals in cells.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To investigate the relationship between expression of p53mRNA and bcl 2,bax protein,and their clinicopathologic features.Methods:Expression of bcl 2,bax protein and p53mRNA in 52 cases of surgically resected primary lung cancer were investigated respectively by immunohistochemical and RT PCR techniques.Results:The positive expression of bcl 2,bax protein was observed in 52(42.3 % vs 59.61 %) cases.The bcl 2 expression rate was much higher in those with poor differentiation and in stage Ⅲ than those with well differentiation and stage Ⅰ ( P 0.01).Conclusion:Overexpression of bcl 2 protein is predominantly observed in lung cancer at late stage;p53mRNA and bax protein play a key role in early stage.They modulate and co operate the balance status of death and survival signals in cells.

Key concepts: BAX Protein, Immunohistochemistry, Lung cancer, Stage (stratigraphy), Protein expression, Lung, Apoptosis, Bcl-2-associated X protein

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
THE EXPRESSION OF bcl-2,bax PROTEIN AND p53mRNA IN LUNG CANCER — Research Paper | ScholarLens