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Pharmacokinetics and relative bioavailability of glipizide

Yang Liu

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Abstract

Objective: To study the pharmacokinetics and relative bioavailability of glipizide tablet. Methods: The glipizide concentrations in sera of 20 subjects were determined by HPLC following an oral single dose of 10 mg. The statistical moment theory was used to calculate the pharmacokinetic parameters. Results: The average pharmacokinetic parameters after oral single dose of the test drug and the reference drug were as follows: AUC 0～∞ :(5 763±1 613) and (5 554±1 365) h·ng/ml; T max :(3.00±1.18) and (3.60±1.72) h; c max :(939.5±233.3) and (819.8±213.8) ng/ml; MRT:(8.09±1.66) and (8.74±2.28) h; t 1/2 :(4.827±1.226) and (5.123±1.421) h respectively;relative bioavailability F 0～24 was (104.8±15.4)%. Conclusion:The two preparations are bioequivalent. There is no significant difference in pharmacokinetic parameters between two preparations. The results are same as those reported in references.

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What this paper is about

Objective: To study the pharmacokinetics and relative bioavailability of glipizide tablet. Methods: The glipizide concentrations in sera of 20 subjects were determined by HPLC following an oral single dose of 10 mg. The statistical moment theory was used to calculate the pharmacokinetic parameters. Results: The average pharmacokinetic parameters after oral single dose of the test drug and the reference drug were as follows: AUC 0～∞ :(5 763±1 613) and (5 554±1 365) h·ng/ml; T max :(3.00±1.18) and (3.60±1.72) h; c max :(939.5±233.3) and (819.8±213.8) ng/ml; MRT:(8.09±1.66) and (8.74±2.28) h; t 1/2 :(4.827±1.226) and (5.123±1.421) h respectively;relative bioavailability F 0～24 was (104.8±15.4)%. Conclusion:The two preparations are bioequivalent. There is no significant difference in pharmacokinetic parameters between two preparations. The results are same as those reported in references.

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Available abstract

Objective: To study the pharmacokinetics and relative bioavailability of glipizide tablet. Methods: The glipizide concentrations in sera of 20 subjects were determined by HPLC following an oral single dose of 10 mg. The statistical moment theory was used to calculate the pharmacokinetic parameters. Results: The average pharmacokinetic parameters after oral single dose of the test drug and the reference drug were as follows: AUC 0～∞ :(5 763±1 613) and (5 554±1 365) h·ng/ml; T max :(3.00±1.18) and (3.60±1.72) h; c max :(939.5±233.3) and (819.8±213.8) ng/ml; MRT:(8.09±1.66) and (8.74±2.28) h; t 1/2 :(4.827±1.226) and (5.123±1.421) h respectively;relative bioavailability F 0～24 was (104.8±15.4)%. Conclusion:The two preparations are bioequivalent. There is no significant difference in pharmacokinetic parameters between two preparations. The results are same as those reported in references.

Key concepts: Bioavailability, Pharmacokinetics, Bioequivalence, Glipizide, Pharmacology, Chemistry, Chromatography, Medicine

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