Study on the pharmacokinetics and relative bioavailability of glipizide in human

Objective To study the pharmacokinetics and relative bioavailability of glipizide in human. Methods The plasma concentrations of 10 subjects were determined by HPLC after 5mg single dosage glipizide capsules and tablets were taken orally and crossly. The results were fitted with MCPKP programm to get pharmacokinetic parameters. Then the relative bioavailability of capsule was caculated. Results The pharmacoki netics parameters of capsule were as following, Cmax 456ng/ml, Tman 3. 0h, AUC 2335h·ng/ml. Above parameters of two preparations had no significant difference by double single t-test and 1-2α confidence interval analysis. The relative bioavailability of glipizide capsule was(103±4) %. Conclusion The plasma concentration of glipizide capsule attach peak in(2.95±0. 6)h, its peak concentration is (456±60)ng/ml. Capsule and tablet of glipizide are bioequivolent preparations.