Pharmacokinetics and Bioavailability of Glipizide in Healthy Volunteers

Objective The pharmacokinetics and relative bioavailability of Glipizide tablets were determined after administration of a single oral dose of 10mg to each of 18 Chinese healthy male volunteers in an open,randomized crossover study. Methods The drug concentration in plasma was assayed by HPLC. Results The pharmacokinetic parameters of two brands Glipizi datablet were:T1/2(3.239±0.69)and(3.461±0.59)h,Cmax(675.3±151.7)and(647.1±166.7)mg·L-1,Tmax(2.389±0.50)and(2.333±0.49)h,AUC0-t(3565.4±733.4)and(3304.8±588.4)μg·h·L-1. Conclusion There is no significant difference between the two products.The relative biaovailability of two brands Glipizi is 93.204%.The result demonstrates that the two preparations are bioequivalent.