Study on the Relationship between Adiponectin and Insulin Resistance, Endothelium-de-pendent Vasodilatation in Obese Patients

Objective: To investigate the relevance of adiponectin to insulin resistance and the endothelium-dependent vasodilatation in obese patients. Methods:The endothelium-dependent relaxing function of right brachial artery and intima-media thickness(IMT) of common carotid arteries were detected by high resolution ultrasound and serum lipids, serum glucose, fasting insulin(FINS), von Willebrand factor (vWF), plasminogen activator inhibitor-1(PAI-1) and adiponectin were measured in 53 obese patients and 24 control subjects. Homeostasis model assessment(HOMA) was applied to assess the status of insulin resistance. Results: Waist-hip-rate(WHR), body mass index(BMI), body fat content(BF), systolic blood pressure(SBP), diastolic blood pressure (DBP), apolipoprotein B(ApoB), fasting blood glucose (FBG), fasting insulin(FINS) and HOMA-IR in obese patients were significantly higher than those in control subjects(P0. 05). Adiponectin were remarkably decreased in obese patients compared with that in control subjects. In all subjects,spearman correlation analysis showed that adiponectin was positively correlated to sex(male=l, female=2), high density lipoprotein-cholesterol(HDL-C)(r=-0.354 and 0.438 respectively, P = 0.027 and 0.005 respectively) and negatively correlated to weight, waist(W), triglyceride(TG), WHR, FINS and HOMA-IR(r= -0.358, -0.359, -0.449, -0.375, -0.363 and -0.319 respectively, P=0.025, 0.025, 0.004, 0.019, 0.027 and 0.054 respectively). Multiple stepwise regression analysis showed BMI and BF were the independent risk factors affected the adiponectin. Conclusion: There was decreased serum adiponectin in obese patients and probably related to insulin resistance.