Clinical trial of Batroxobin injection in the treatment of acute cerebral infarction

Objective This paper is to evaluate the efficacy and safety of batroxobin in treatment of acute cerebral infarctions.Methods A multicenter,randomized,doubleblind,placebo controlled clinical trial was conducted,including a test group and a control group.The patients in each group were treated with wei nao lu tong injection(a kind of traditional treatment in acute cerebral infarctions)as a basic treatment.Batroxobin was added to the test group,while the placebo (normal saline) was added to the control group every other day for 3 days altogether.Results The clinical effects in the test group were observed significantly earlier than the control group,and the neurological function was recovered significantly better than the control group even at 10 days after batroxobin treatment had been stopped.The serum fibrinogen level was decreased significantly in the test group,and the side effects were well tolerated.Conclusion Batroxobin is effective and safe in treatment for patients with acute cerebral infarctions.