Clinical evaluation of propess for cervical ripening in term pregnancy

To explore the efficacy and safety of continuously releas ed prostaglandin E 2 (PGE 2) suppository-propess used for cervical ripening in ter m pregnancy Methods: A double-blind, randomized, case-control clinical study w as conducted, propess was used in 50 cases as study group, Prepidil was used i ntracervically in 40 cases as control group The cervical maturity (by Bishop s c oring), condition of delivery, fetal and neonatal condition were compared betwee n two groups Results: Bishop score was 6 2±1 1 and 7 7±1 3 respectively after using propess 6 and 12 hours in the study group, which was significantly higher than that of control group (4 8±1 2, 6 8±1 1, respectively, P0 01) The time to labor starting, membrane rupture was shortened obviously in study group than that of control group (P0 01) There was no significant difference between two g roups in total duration of delivery, cesarean section rate, postpartum hemorrhage, fetal and neonatal conditions The major side-effect of propess was overstimulation of uterine contraction Conclusion: Propess can be used for cervical ripening safely and effectively