Clinical evaluation of propess and prasterone for induction of term pregnancy

Objective To evaluate the efficiency and safety of propess(Prostaland in E2) for cervical ripening and induction of term pregnancy.Methods 164 primigarae matched the requirements entered this case controlled study.The patients were randomly divided into two groups:82 in propess group,and 82 in praterone group,propess group received a propess pessary inserting into posterior vaginal fornix,and controlled group was given 200mg prasterone intravenously per day for three days.Efficiency of cervical ripening,vaginal labor and newborn's Apgar score were compared between the two groups.Results The total efficiency of cervical ripening was 93.90% in the propess group and 4.88% in controlled group(P0.01).The mean time of drug administration to appearance of uterin contraction,labor starting and labor in propess group were less than controlled group(P0.01),the ratio of cesarean section in experimental group was significantly lower than in controlled group(propess group 25.6%,controlled group 42.68%).No significant differences were found in the total labor time,postpartum hemorrhage,fetal heart rate disorder and meconium-stained amniotic fluid bewteen the two groups(P0.05).The mean weight of newborn and the ratio of fetal distress were also found no significant differences between the two groups(P0.05).Conclusions Propess is effective and safety in producing cervical ripening and inducing labor.