ScholarLens Back to search
2001•Journal of Practical Aesthetic and Plastic SurgeryRequires access

The effect of extrinsic hyaluronic acid on collagen metabolism in experimental wound healing

Wang Ji-hui

Open publisher page 0 citations

Abstract

Objective By detecting the influence of hydroxyproline on collagen metabolism of wound healing of rabbit ear to investigate the inhibition effect of hyaluronic acid on scar proliferation. Methods Wound healing model were made on the ears of 18 rabbits. They were randomly divided into 2%HA treated-group(group A), 1%HA treated-group(group B) and normal saline treated-group(group C). The wound area skin was obtained at different days after operation. Tissue hydroxyproline was detected. Data was analyzed statisticaly. Results The hydroxyproline content in group A and B were lower than group C (P0.01). The difference between group A and B was also prominent (P0.05). Conclusion Hyaluronic acid can inhibit the collagen synthesis. The dependence relationship between effect and dosage is notable.

About this research paper

What this paper is about

Objective By detecting the influence of hydroxyproline on collagen metabolism of wound healing of rabbit ear to investigate the inhibition effect of hyaluronic acid on scar proliferation. Methods Wound healing model were made on the ears of 18 rabbits. They were randomly divided into 2%HA treated-group(group A), 1%HA treated-group(group B) and normal saline treated-group(group C). The wound area skin was obtained at different days after operation. Tissue hydroxyproline was detected. Data was analyzed statisticaly. Results The hydroxyproline content in group A and B were lower than group C (P0.01). The difference between group A and B was also prominent (P0.05). Conclusion Hyaluronic acid can inhibit the collagen synthesis. The dependence relationship between effect and dosage is notable.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective By detecting the influence of hydroxyproline on collagen metabolism of wound healing of rabbit ear to investigate the inhibition effect of hyaluronic acid on scar proliferation. Methods Wound healing model were made on the ears of 18 rabbits. They were randomly divided into 2%HA treated-group(group A), 1%HA treated-group(group B) and normal saline treated-group(group C). The wound area skin was obtained at different days after operation. Tissue hydroxyproline was detected. Data was analyzed statisticaly. Results The hydroxyproline content in group A and B were lower than group C (P0.01). The difference between group A and B was also prominent (P0.05). Conclusion Hyaluronic acid can inhibit the collagen synthesis. The dependence relationship between effect and dosage is notable.

Key concepts: Hydroxyproline, Hyaluronic acid, Wound healing, Saline, Group A, Group B, Chemistry, Surgery

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The effect of extrinsic hyaluronic acid on collagen metabolism in experimental wound healing — Research Paper | ScholarLens