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Expression of BAG-1 and its clinical significance in breast cancer

DU Jing-li

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Abstract

OBJECTIVE:To detect the expression of BAG-1 in breast cancer and evaluate its clinical significance.METHODS:The expression of BAG-1 in breast cancer was detected by immunohistochemical staining with DAKO EnVision System,and its clinical significance and bionomics were evaluated.RESULTS:The staining of BAG-1 was buffy and mainly located in the cytoplasm of positive cells.The positive rates of BAG-1 in all detected cancers were higher than those in their control hyperplasitic tissue and normal tissue.There was a significant difference of positive rates between the cancer tissue and the normal tissue,P0.05.The expression of BAG-1 in breast cancer was not related to the sizes,grades,and metastasis of axillary nodes,but it was correlated with the 5 year survival rate significantly,and related to the expressions of ER,PR and HER-2 in breast cancer,P0.01.CONCLUSION:It is significant to evaluate the clinical characteristics and prognosis with the expression of BAG-1 in breast cancer.

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OBJECTIVE:To detect the expression of BAG-1 in breast cancer and evaluate its clinical significance.METHODS:The expression of BAG-1 in breast cancer was detected by immunohistochemical staining with DAKO EnVision System,and its clinical significance and bionomics were evaluated.RESULTS:The staining of BAG-1 was buffy and mainly located in the cytoplasm of positive cells.The positive rates of BAG-1 in all detected cancers were higher than those in their control hyperplasitic tissue and normal tissue.There was a significant difference of positive rates between the cancer tissue and the normal tissue,P0.05.The expression of BAG-1 in breast cancer was not related to the sizes,grades,and metastasis of axillary nodes,but it was correlated with the 5 year survival rate significantly,and related to the expressions of ER,PR and HER-2 in breast cancer,P0.01.CONCLUSION:It is significant to evaluate the clinical characteristics and prognosis with the expression of BAG-1 in breast cancer.

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Available abstract

OBJECTIVE:To detect the expression of BAG-1 in breast cancer and evaluate its clinical significance.METHODS:The expression of BAG-1 in breast cancer was detected by immunohistochemical staining with DAKO EnVision System,and its clinical significance and bionomics were evaluated.RESULTS:The staining of BAG-1 was buffy and mainly located in the cytoplasm of positive cells.The positive rates of BAG-1 in all detected cancers were higher than those in their control hyperplasitic tissue and normal tissue.There was a significant difference of positive rates between the cancer tissue and the normal tissue,P0.05.The expression of BAG-1 in breast cancer was not related to the sizes,grades,and metastasis of axillary nodes,but it was correlated with the 5 year survival rate significantly,and related to the expressions of ER,PR and HER-2 in breast cancer,P0.01.CONCLUSION:It is significant to evaluate the clinical characteristics and prognosis with the expression of BAG-1 in breast cancer.

Key concepts: Breast cancer, Clinical significance, Immunohistochemistry, Medicine, Cancer, Pathology, Breast tissue, Staining

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