Comparability research on human chorionic gonadotropin results among different kinds of chemiluminescence immune detection system

Objective To discuss the comparability of human chorionic gonadotropin (HCG) results among different detection system.Methods Four different kinds of chemiluminescence immune detection system (Bayer ACS:180,Bayer CENTAUR,Johnson VITROS ECI and DPC immulite-1000) were used to detect HCG concentration in 3 kinds of quality control specimen (Bayer,DPC and self-made) and 34 clinical sera.The collected data were deal with statistics analysis.Results Analysis of variance showed the HCG results from different control and patients sera had significant difference in different detection system (P 0.01).The correlation coefficient of each detection system was above 0.975 and the reliability coefficient of them all were close to 1.We regarded ACS:180 as standard detection system and evaluated the acceptability of other detection system.As a result,CENTAUR and VITROS ECI were partly accepted and immulite-1000 couldn't be accepted by clinic assessment.Conclusion The precision of HCG results in the 4 kinds of detection system accorded to clinic requirement.However,incomparability existed in the evaluation of clinical acceptability.