Comparability research on TSH results among different detection systems

Objective To discuss the comparability of TSH results among different detection systems.Methods 4 different kinds of chemiluminescence immune detection systems (Bayer ACS180, Bayer CENTAUR, VITROS ECI and DPC immulite-1000) were used to detect TSH concentration in 3 kinds of quality control specimens (Bayer,DPC and self-made) and clinical sera. The collected data were dealt with statistical analysis.Results Analysis of variance showed the TSH results from different control and patients sera had significant difference in different detection systems (P0.01). The correlation coefficient of each detection system was above 0.975 and the reliability coefficient close to 1. CENTAUR was regarded as the standard detection system and used to evaluate the acceptability of other detection systems. As a result, ACS 180 was accepted and VITROS ECI and immulite-1000 were partly accepted by clinic assessment.Conclusion The precision of TSH results in the 4 kinds of detection systems accords to clinical requirement. However, incomparability exists in the evaluation of clinical acceptability.