Approach of clinical significance of serum C-respective protein and matrix metalloproteinases-2 levels in acute coronary syndrome patients

Objective:To investigate the relationship between serum levels of C-respective protein (CRP)and matrix metalloproteinases-2(MMP-2) and coronary atherosclerotic plaque rupture and its significance as serum target of plaque rupture. Method:The levels of CRP and MMP-2 in peripleral serum of 40 acute coronary syndrome(ACS) patients, stable angina pectoris(SAP) patients and 40 without coronary heart disease patients as control were measured, respectively by enzyme-linked immunoassay(ELISA) and scatter rateturbidity.Result:The serum levels of CRP and MMP-2 in ACS group, SAP group were higher than that in without coronary heart disease group.The levels of CRP and MMP-2 in ACS group were higher than that in SAP group.There was a positive correlation between the levels of CRP and MMP-2. Conclusion:Elevation of serum level of CRP and MMP-2 are related with unstable plaque. It can be used as a serum target to judge plaque rupture.