Changes and its significance of serum content of soluble CD40L and C-reactive protein in patients with acute cerebral infarction

Objective To investigate the changes and its significance of serum content of soluble CD40L(sCD40L) and C-reactive protein(CRP) in patients with acute cerebral infarction(ACI).Methods The content of serum sCD40L and CRP in 40 patients with ACI and 30 normal controls were measured by enzyme-linked immuno-sorbent assay and immunonphelometry.The content of serum sCD40L and CRP were compared in the patients of different pathogenetic condition and infarction size.The correlation between sCD40L and CRP and pathogenetic condition and infarction size were analysised.Results The contents of serum sCD40L and CRP in ACI group were significantly higher than normal control group(all P0.01).The content of serum sCD40L and CRP in the patients with serious state of illness and large size infarction were significantly higher than those in the middle-light state of illness and small size or lacuna infarction groups,the patients with middle state of illness,small size infarction were significantly higher than those in the light state of illness and lacuna infarction groups(allP0.05).The content of serum sCD40L had positive correlation with the content of CRP(r=0.817,P0.01).Conclusions The contents of serum sCD40L and CRP increase in the patients with ACI,and witch are correlated with the illness state and infarction size.Which register that sCD40L and CRP are the indexes of serum biology in ACI condition.