Study on anti-aging effect of Lycium ruthenicum Murr

Objective To study the effect of Lycium ruthenicum Murr,on the learning,memory and antioxidant ability of aging mice induced by D-galactose.Methods Aging model was induced by subcutaneously injecting mice with D-galactose.At 6 weeks after administration of aqueous extract of Lycium ruthenicum Murr.,the water maze was used to determine the function of learning and memory,the analytic kit was used to measure the activity of superoxide dismutase(SOD),the contents of malondialdehyde(MDA) and lipid peroxidation(LPO) in brain of mice,as well as the activity of SOD,the contents of MDA and glutathione peroxidase(GSH-Px) in serum of mice.Results Lycium ruthenicum Murr.could reduce the escape latency,swimming total path,shorten the time in the near station,significantly shorten the time and swimming path in the distant station area to stay,increase the residence swimming path in the area close to the table and the average swimming speed of aging model mice in a water maze.Besides,it could reduce MDA content and increase GSH-Px content and SOD activity in serum,increase SOD activity and reduce LPO and MDA contents in brain(P 0.05,P 0.01).Conclusion Lycium ruthenicum Murr.has anti-aging effect on aging model mice,and the mechanism may be related to improving learning and memory and enhancing antioxidant ability in aging mice.