Therapeutic Efficacy of Naoxintong Capsules on Vascular Dementia and Effect of It on Oxidative Stress

OBJECTIVE:To observe the clinical efficacy of Naoxintong capsules in the treatment of mild and moderate vascular dementia(VD)and the effect of it on oxidative stress of patients.METHODS:78 cases of VD were randomly divided into control group and treatment group with 39 cases in each group.Control group was given Nimodipine tablets 1 piece pertime,3 times a day and treatment group was given Naoxintong capsule 2-4 pieces each time,3 times a day.A course of treatment lasted for 6 months.Before and after treatment,Mini-mental state examination scale(MMSE)and Kyohko Hasegawa simple intelligence rating(HDS),activity of daily living scale(ADL)were used to determine oxidative stress index,and clinical efficacy was evaluated by MMSE and symptom improvement,and adverse drug reactions were recorded during treatment.RESULTS:The total effective rate of treatment group was 84.6%,and similar to the control group;MMSE,HDS and ADL score and oxidative stress index of 2 groups were improved after treatment(P0.05 or P0.01),and the improvements of MMSE and ADL score,MDA,SOD and GSH-PX activity in treatment group were better than in control group(P0.01 or P0.05).Adverse drug reactions were mild in 2 groups.CONCLUSION:Naoxintong capsule can be effectively used in the treatment of mild to moderate VD.