The Application of Protective Mechanical Ventilation on Meconium Aspiration Syndrome in Neonates

Objective To assess the efficacy of exogenous pulmonary surfactant(PS) combined with protective lung mechanical ventilation on meconium aspiration syndrome(MAS).Methods Thirty five infants with MAS received PS(200 mg/kg) via tracheal intubations were randomly divided into group A and B.All 18 infants in group accepted conventional mechanical ventilation;however,17 patients from group B were performed by protective lung mechanical ventilation.To observe the clinical manifestation and detect the changes of PaO_2 and oxygenation index(OI) within 24 h after treatment in patients. Results The mortality(5.71%) and complications in the patients of group B were less than that in group A.The OIs of group B were lower than those of group A during various time after treatment.(P0.01).the oxygenation index in groups B was significantly lower than that in group A(P0.01).Conclusions The combination of exogenous PS with protective lung mechanical ventilation exerts synergistic action on the MAS,could increase curative effect and decrease incidence of complications.