Expression and clinical significance of ER,PR,C-erbB-2 and p53 in 87 cases of thyroid carcinoma

Objective:To study the expression of the estrogen receptor(ER),progesterone receptor(PR),C-erbB-2,p53 in thyroid carcinoma and their clinical significance.Methods:ER,PR,C-erbB-2,p53 in 87 cases of thyroid carcinoma,20 cases of adinoma and 20 cases of adjacent normal tissues of thyroid tumor were exmined using the method of immunohistochemistry S-P.Results:The positive rates of ER and PR were 64.4% and 63.2% respectively in thyroid carcinomas,which correlated with differentiation and histologic types,however did not relate to age and sex.The positive rates of ER and PR in the nonmetastatic group were 75.4% and 70.5%,significantly higher than those of the metastastatic group which were 53.8% and 46.2%(P0.05).The expression of C-erbB-2 was increased with increasing of differentiation of the carcinoma.The expression of p53 was decreased with the increasing degree of differentiation.A significant inverse correlation was found beteen p53 and c-erbB-2.The positive rate of C-erbB-2 was obviously higher in the metastastatic cases(P0.01).Conclusion:The expression of ER,PR,C-erbB-2 and p53 were related to tumor differentiation and the degree of malignancy and may indicate a poor prognosis.