EXPRESSION OF ER,PR,AR,RECEPTORS AND C-erbB-2,p16, p53 GENE PROTEINS IN BREAST CANCER

The significance of ER,PR,AR,receptors and C\|erbB\|2 protooncogene,p16,p53 tumor supprssor genes in the cevelopment and pathologic diagnosis,grade of breast cances was eraluated.The exprssion of ER,PR,AR receptors and C\|erbB\|2,p16,p53 gene proteins was detected immunohistochemically in 62 cases of breat carcinoma and 10 cases of benign breast lesions.Results the immunoreactivity for ER,PR,AR,C\|erbB\|2,p16,p53 in this group was 85.5%, 74.2% 22.6%,74.2%,90.3%,48.4%,respectively,showing a significant difference( P 0.001 ) between the benign group and the malignant group,no differece( P 0.05 ) between the different histologic types;nuclear pleomorphism is distinctly rlated to the expression of p16,PR( P 0.05 );ER is related to p16,tumor gland grade,histologic grade ;and PR to p16,AR to p53,ptient age;p53 to nuclear pleomorphism,mitotic rate,histologic grade;tumor size to lymphatic node metastatic rate and all of them are interrelated as shown in the abve, ER\,PR\,AR are good signs for the endocrine therapy of the patients while p16,p53 are useful signs for the tumor prognosis and both markers are associated with the biological behaviours and pathologica characteristics of the breast carcinoma.