Clinical Analysis of Adult Acute Leukemia Chromosome Abnormalities

Objective:Analysis of 74 cases of adult acute leukemia patients with chromosome abnormalities and the distribution of subtypes of karyotype changes in characteristics.Method:On the preliminary diagnosis of acute leukemia morphology,immunology,cytogenetics,molecular biology testing.Result:Chromosomal abnormalities in patients with acute leukemia karyotype in AML,ALL was respectively,64.4%(38/59)and 73.3%(11/15),with an average chromosome abnormalities accounted for 66.2%(49/74).Chromosome abnormalities from the view of the characteristics,M3 more consistent chromosomal change according to t(15;17)(q22;q11.2)changes in the main;while other types of leukemia,there was inconsistency chromosomal abnormalities,especially in M4 there was a clear inconsistent.Conclusion:Acute leukemia according to analysis of chromosomal abnormalities,complex karyotype is a sign of poor prognosis.Some of the specific chromosomal abnormalities and the FAB subtypes closely related.Therefore,the chromosomal abnormality karyotype analysis in leukemia diagnosis,classification,treatment and prognosis aspects play an important role.